Editorial: NAR Awards 2012
نویسندگان
چکیده
Amanda Nga-Sze Mak (Fred Hutchinson Cancer Research Center, Seattle, WA, USA) The Crystal Structure of TAL Effector Pthxo1 Bound to its DNA Target Amanda Nga-Sze Mak, Philip Bradley, Raul A. Cernadas, Adam J. Bogdanove, Barry L. Stoddard The crystal structure of PthXo1 bound to its DNA target was determined with the use of a novel high-throughput computational structure prediction method, that was subsequently validated by heavy-atom derivitization. The structure illustrates the structural basis for site recognition by TAL effectors, which are now used by many laboratories for targeted gene modification experiments.
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